They built the city to see what makes us tick. Last night one of us went off.
Separated from his wife, Emma (Jennifer Connelly), amnesiac John Murdoch (Rufus Sewell) awakens alone in a strange hotel to learn he is wanted for a series of brutal murders, but he can't remember if he committed them or not. Indeed, most of his memories have completely vanished, and he becomes the focus of interest for both "mad genius" Dr. Schreber (Kiefer Sutherland) and sympathetic detective Frank Bumstead (William Hurt). Attempting to unravel the twisted riddle of his identity, Murdoch encounters a group of ominous beings known as the "Strangers," shadow-like figures who have collective memory and posses the ability to stop time and alter physical reality through a process called "The Tuning."